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have only within the past five years become a victim of the dreaded P.
Along with this I have become diabetic, developed a mutilating
arthritis in my spine, hands and feet, and been diagnosed with chronic EBV.
Sound fun? Of course not!
P has never been cleared and eight of my ten finger nails are inflicted by
P. They tend to be eaten down to the quick and then they separate from the
nail bed. I have been on every single oral and topical treatment including
MTX [methotrexate] and I can not take the MTX anymore due to liver
toxicity. They are suggesting Soriatane, but I if it can cause liver
dysfunction I am worried it will not work. Has anyone had good results
without bad side effects from this? -Kristi
Response: No, your litany of ills does not sound like fun, Kristi.
I was stumped by chronic EBV.
Is this Epstein-Barr virus? If
so, I read about it at webMD.com. In the article hyperlinked here, they say chronic EBV used to
be confused with CFS — chronic fatigue syndrome. You need to scroll down
in the hyperlinked article to get to the discussion of EBV:
Epstein-Barr virus (EBV) causes infectious mononucleosis, which is marked
by fatigue and swollen glands; it primarily affects adolescents and young
my current round of methotrexate therapy winds down (for whatever reason),
if I’m not cured <happy fantasy> I will probably try soriatane.
Laboratories Inc. has mounted an impressive web site about soriatane
(acitretin). Once there, look
for the small type hyperlink “Complete Product Information” and
you’ll get the small print stuff with the most revealing information.
I lifted this from that section:
of AST (SGOT), ALT (SGPT), GGT (GGTP) or LDH have occurred in
approximately 1 in 3 patients treated with Soriatane. Of the 525 patients
treated in clinical trials in the US, treatment was discontinued in 20
(3.8%) due to elevated liver function test results. If hepatotoxicity is
suspected during treatment with Soriatane, the drug should be discontinued
and the etiology further investigated.
flaker Mark Shaw has almost got me looking forward to a course of
soriatane. He’s got his own
site. Check out Mark’s
“History” starting in the year 2000.
The very first entry in his journal for 2000 is about side effects
from soriatane (he calls it Acitretin throughout his journal).
Reading his entries from that point forward gives you as honest an
accounting of one man’s experiences as I’ve encountered.
Like I said, Mark’s almost got me looking forward to trying
Please keep us apprised of your progress, Kristi. -Ed