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Combination Therapy Studied (Again)
My son, 22 years old, is currently on cyclosporine but will have to
come off soon so I have been desperately looking for anything new to help
him. I came across this and
thought you might be interested since you are considering Amevive.
It is a paragraph from the following article:
Response: Thanks for the link
and the quote, Bettye. I
always find studies like this interesting — probably because I’m never
quite sure what to conclude from them.
If I understand the research results correctly, (1) everybody got
better, meaning those that took only Amevive, those that took Amevive plus
conventional UVB, and those that took Amevive plus narrowband UVB; (2)
those who had light therapy with Amevive got slightly better than those
who took Amevive alone over the 6 week period; and (3) those who took
Amevive alone got a little bit better, statistically, in 6 weeks, than
earlier studies would have predicted.
important (I guess) conclusion from this study is that the combination
therapy involving Amevive and UVB (conventional OR narrowband) doesn’t
seem to bring on any more adverse reactions than have been noted with any
of these therapies singly. Which
means together they work slightly better than any of them alone, and
together they don’t aggravate each other.
To me this
means one more strategy in our armory to combat P.
We also need to bear in mind that Amevive by itself is expensive
$10,000-$15,000 for a 12-week course.
Presumably, a concurrent course of light therapy requiring
dermatology office visits, would add to this cost.
Here’s what I
would do with this information IF I could tolerate UVB light therapy
(which I can't). I would start
my course of Amevive assuming the best with no combination therapy.
In about six weeks I’d ask my derm to assess my progress.
If my derm and I agree that I’m not improving as much as I should
be, then I would consider adding the UVB therapy (if my insurance pays for
Though I am
planning to start Amevive in early 2004, I doubt whether the UVB therapy
addition will ever be an option for me.
All my earlier attempts at UVB/A light therapy regimens (including
PUVA) have failed because my skin won’t tolerate enough exposure to the
rays. In short, I
“sunburn” too easily.
I’d appreciate hearing from anyone who does try the Amevive/UVB combo therapy. -Ed