Sep-Oct '09 | briefing | mail | interviews | articlespsorchat |  don't say this | flaker creativity | flakers' jargon | spouses corner | other places | archives | send mail | ed dewkesearch | acknowledgments | legal stuff | Flake: Confessions of a Psoriatic  | 2009 FlakeHQ, Inc.

Lesions Diminishing with Ongoing Use of LDN
from Jeni S.

I’ve had psoriasis all over the place, including my face, for about 12 years now and in the past have used mainly Dovonex, Dovobet, other sticky creams and UVB a few times, which worked well the first time but not so well after that. I’ve been taking LDN [low dose naltrexone] now for about 4 months starting at 1mg/day and now at 3/3.5mg, which is supposed to be the optimum dose. I didn’t really notice much of a change for the first couple of months, but it has definitely faded over the last month or so and I can even see skin on my knees (total novelty!). My face has also completely cleared up. Obviously this has also coincided with summer, so the sun may have played some part, but it is better than it has been for a long time, so I feel the LDN is definitely helping – hopefully it’ll continue to improve. There are no side effects from taking LDN (apart from a few strange dreams to begin with!) and it’s reassuring to know that the drug has been on the market albeit at higher doses and for other uses for about 20 years. I’d be very interested to know of anyone else who’s trying LDN. I believe there are plans for some trials at a dermatology clinic in Scotland, although since drugs companies aren’t that interested in a drug that’s already on the market, funding is the main problem. There are two websites that provide some useful info – and – if anyone wants to know more.  Cheers, -Jeni


Ed's Response:


I'm delighted to hear about your improvement using LDN. Though it is virtually impossible to launch a wide scale phased study on this established and now patent-exclusivity-expired drug, it's encouraging to learn that off-label use of the drug for immune system related disorders continues here and abroad. Almost all of the systemic drugs used to combat psoriasis today were designed with other diseases in mind. Most enjoyed years of success targeting the initial disease before FDA approval to include psoriasis was obtained. LDN's lack of side effects makes it sound safer than either methotrexate or cyclosporine.

I read at that the normal off-label dose for non-addiction* prescribing was 4.5 mgs per day. -Ed

* Naltrexone itself was approved by the FDA in 1984 in a 50mg dose for the purpose of helping heroin or opium addicts by blocking the effect of such drugs. -

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