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C and Flaking
Ed: I have just found your
site and find several people discussing methotrexate.
went to a doctor for my husband's psoriasis.
He prescribed methotrexate for Paul but thankfully also ordered a
blood test that would alter our lives.
He had Paul's liver enzymes checked because methotrexate can affect
the liver. Through a
series of tests, Paul found he had Hepatitis C.
we find that psoriasis is a side effect of Hep C.
He had psoriasis for 20 years prior to our finding out about the
Hep C. Then Paul's finger
swelled up and we found out he had psoriatic arthritis.
Our specialist said it was not connected to the Hep C, but we have
found that it is.
get liver enzymes checked before going on methotrexate.
If you have psoriasis and Hep C, do NOT go on ribavirin/interferon
treatment, as it may aggravate the P into an arthritic condition.
was pulled off the above R/I medication after two weeks being on it.
The virus was activated, angry and now, two months later, Paul has
a bad case of psoriatic arthritis.
wish doctors knew what they
were doing. -Linda
Response: It sounds like
Hepatitis C and/or the ribavirin/interferon regimen might have contributed
to triggering Paul’s P-arthritis, but I hesitate to accept your
statement that “psoriasis [or psoriatic arthritis] is a side effect of
Hep C.” A significant percentage of flakers eventually develop PA with
or without the Hepatitis C connection, you may just be in a position to
point definitively to Hep C as Paul’s trigger.
By the same token, I’m under the impression that many people
diagnosed with Hep C don’t have P.
If there’s a statistical correlation that justifies the claim
“side effect” I’m unaware of it.
developed PA in my right knee in the mid-90s.
It worsened in the late 90s and migrated to fingers and feet (as
well as the knee). Methotrexate
(MTX) was the drug that finally calmed down the PA (and successfully
moderated most of the plaque P as well).
yes, the blood workup prior to commencing an MTX regimen should always be
done. In fact, when I was
first considered for MTX in the early 90s, it was ruled out because of
liver enzyme anomalies.
I share your impatience with the doctors. There seems to be an awfully lot of them that don’t know much about P. -Ed