Depression & Psoriasis by Stacy

Hello Ed. I am 29 years old and have had psoriasis for 26 years. I am currently taking methotrexate (for almost 2 years). The first 1-1/2 years was great, now the effectiveness is diminishing. But, that's a whole other story.

The real reason I'm writing is to tell you of my experiences with anti-depressants. I've taken several: Pamelor, Luvox, Prozac (just to name a few), and currently take Effexor. I can honestly say that I've never been able to attribute improvement or worsening of the P to any anti-d that I've taken. Interestingly enough, I've also taken Lithium (which has been reported to have an adverse effect on psoriasis) and seen no changes in severity. Thankfully, I am not currently depressed, so the medication is working, but, as I said before, I can not clearly report any change in my skin from the medications mentioned above.

Keep up the great site, and thanks for listening. -Stacy

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Ed's Response:

Dear Stacy: You are one of several people who've answered my call for experiences with antidepressants and P. So far, no one has suggested a correlation. I guess that's good; however, it does put a damper on my using my P as an excuse for being in a bad mood.

Obviously our dialogue here carries no scientific validity, but from a pragmatic angle it would seem P and clinical depression (at least) are not tightly associated (if at all). This would justify a psoriatic's pursuit of OTHER SOLUTIONS if depression is a problem. In other words, it would probably not be safe for a psoriatic to assume he or she is depressed because of his or her psoriasis. (That notion should make greedy GPs and shrinks very happy.) Thanks for your contribution to the on-going dialogue. -Ed

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