Jul-Aug '08 | briefing | mail | interviews | articlespsorchat |  don't say this | flaker creativity | flakers' jargon | other places | archives | send mail | ed dewkesearch | acknowledgments | legal stuff | Flake: Confessions of a Psoriatic  | 2008 Ed Dewke

Dovobet Caused Flaring for Mom and Son
from Nat

I had minimal patches on elbows and belly button when I started using Dovobet about a month ago. I now have psoriasis spreading like wildfire down to my feet, all over my arms, legs, back and chest. My mum tried it on her elbows and said that she also suffered the most terrible flare up.

I am therefore really not very sure about this product.


Ed’s Response: Wow, this sounds extraordinary, Nat. The worst adverse reaction I could find described about Dovobet was 9.9% lesional or perilesional adverse reactions.

Dovobet emerged in the U.K. after the therapeutic use of Dovonex (a synthetic vitamin D3 derivative, non-steroidal) and betamethasone (a strong corticosteroid) were anecdotally proselytized in the United States. Dovonex was being prescribed to folks with significant lesion involvement as it was supposed to be “safer” than topical steroids. When it didn’t work as well as desired, derms started to recommend either alternating between Dovonex and a corticosteroid, or actually mixing the two and applying them together. Dovobet is a commercialized version of the latter.

In the web link cited above, it is also said that generally adverse reactions to Dovobet are not as common or as significant as they are to either of the two combined products when used individually. The massively adverse reactions — flares — that you and your mother have experienced is unusual for either of the key ingredients used alone, let alone the supposedly-more-benign product that combines them both.

Which leads me to wonder if you had an allergic reaction to the product. Have you tried either calcipotriol or betamethasone dipropionate separately?  If so, did either of them cause a similar reaction? What are the inactive ingredients of Dovobet? Might you be allergic to any of them?

In any case, obviously Dovobet is not a good bet for you or your mother. Fortunately, there are other things to try. Thanks for letting us in on this reaction and I hope you find something that works as expected for you.  -Ed

P.S. - In 2006, the calcipotriol/betamethasone combo was finally introduced as a single product in the U.S. as Taclonex.

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