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Bad Reaction During Raptiva Trial
My husband has suffered from psoriasis for over ten years but it
has never been out of control until recently.
His condition has always been plaque psoriasis
Under my encouragement, he consented to participate in a clinical
study, Phase 3, of Efalizumab (Raptiva).
We felt comfortable about our ability and willingness to deal with
the possible side effects that included nausea, chills etc.
Never were we told that crippling joint pain resulting in the
inability to walk was a possible adverse reaction.
During the course of
treatment with Efalizumab my husband experienced swelling and pain that
were unbearable and landed him in the emergency room.
His experiences appear to be similar to those suffered by Lesleigh
who posted a response to your site. My
attempts to contact Lesleigh at the email address contained in the posting
were unsuccessful and I was hoping that you might be able to help us make
a connection. –Gail H.
Sorry to hear about your husband’s bad reaction.
This severe joint pain is beginning to sound like much more than a
statistical anomaly. It sounds
like the reason for the joint pain reaction to Raptiva needs to be
determined — that is, the preconditions to the reaction need to be
identified — and then an appropriate statement contraindicating use of
the drug needs to be promulgated.
I hope Genentech is
taking the right steps. A
short write-up about the Phase III Raptiva trial is contained on
this page at the NPF web site.
Lesleigh has evidently changed email addresses. I have no further contact information. Lesleigh: If you read this, please drop us a line. -Ed