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Amevive Trial Subjects Out There?
Ed. I have a great
relationship with my derm, and trust her completely. She's something of a
psoriasis "junkie" and is very into research. She wants me to
start Amevive as soon as it's available, and while I've read a lot about
it, I've never seen a post
anywhere from a person who's actually been on it. Have you? If so, I'd
love to see it.
more than 25 years of trying everything, this is the first time I'm not
rolling my eyes at or totally freaked out by a treatment option ... I'm actually
kind of (cautiously) excited. Thanks,
Response: Surprisingly, I
can’t find anything written by an alefacept trial participant, either.
It may be that I’m forgetting the trial’s code name.
But there is good information about Amevive (alefacept) at the National Psoriasis Foundation web site:
reading about Amevive has me scratching my head.
Obviously people are excited about the drug because it has so few
(and relatively harmless) short-term side effects.
It’s a systemic drug that goes at the cause of P on a cellular
level (shutting off the function of certain T-cells that otherwise ignite
lesion development), and it does this without bothering a lot of other
immune system functions — which has always been the complaint about
other immune suppressing drugs like Methotrexate and Cyclosporine.
But according to the first article bulleted above, 53% of the trial
subjects improved significantly while on the drug.
I read “50/50 chance of working” in those results.
Am I being overly cynical to suggest I’m not too impressed?
I suppose given
a drug with no bad side effects a 50/50 chance of working in your case is
worth the time and expense. If
you’re unlucky enough to be on the wrong side of the ratio, there are
other — albeit less desirable — alternatives.
And the point needs to be made that other, safer-than-in-the-past
choices are coming into being (Enbrel, Remicade...).
I have a worn
list of topical corticosteroids that has been my a
la carte menu for a decade and everyone knows they shouldn’t be used
continuously for that length of time.
Having choices like Amevive, Enbrel and Remicade — though each
may or may not work for me — could still compel me to throw away that
worn list of goops.
Sometimes I need to remind myself that 99% of progress isn’t accomplished all at once and in a burst of inspiration. Or, the way my grandfather used to put it, “One miracle at a time, Ed. One miracle at a time.” -Ed