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for Xanelim ‘cause anti-CD11a Worked Well
I too was a phase III trial volunteer here in Portland, and also
stumbled across your site after Googling anti-cd11a and will definitely be back. Lots of good links.
I'm 39 and have
had P for about 30 years. If
the cut-off for moderate is 30% coverage, my skin is just ready to tip
from moderate to severe.
utterly fabulous for me during and for a few months after the trial ended.
[At least 11 articles in the
Archives containing “anti-cd11a” — a.k.a. Xanelim, a new biologic
immune-suppressing drug — use Search on the home page. –Ed]
I wore shorts and a tank top or short sleeve shirt comfortably in
public for the first time in probably 20 years. Now it's been somewhere
around 3/4 year since the trial ended. Coverage is probably nearly as
extensive as it was before the trial, but with some changes that are
notable but I would hesitate to say they are due to a rebound effect.
New areas, like
ankles, backs of the knees, upper back/shoulders and, regrettably, face
are flaring. I still have large clear patches on my torso, but they get
smaller by the week. Flakes are much finer, almost like a mist, without
big chunky flakes like before. It’s
as though the spots have gotten thinner.
almost completely clear by poking myself with a needle a couple times a
month, I've been loathe to work hard on it like before. Occasionally UVA
and lots of off the shelf moisturizer is about it. I
also have 2 little ones in diapers, compared to 1 before, a more intense
workplace, world events, domestic terrorism, etc., so who knows if it's a
rebound or just a combination of increased stress and lack of effort on my
part? Nevertheless, I am eager for Xanelim hit the market.
Thanks for the
forum! –Howard R.
Response: I’m so glad you
shared your anti-CD11a success with us, Howard.
Most of the emails in the archives have come from people with less
than satisfactory trial experiences (especially headaches and bad
my spirits about Xanelim quite a bit.
The way I look
at it, rebound is the price we seem to have to pay for any relief that
lasts awhile. The same is true
with ALL the currently approved drugs, including Methotrexate and
Cyclosporine. If you stop
these regimens and don’t immediately start something that’s strong
enough to handle it, rebound happens.
(When I moved from Methotrexate to Cyclosporine a year and a half
ago, for about 3 months we “stepped down” the MTX and “stepped up”
the cyclo. I had no bad
rebound, so either this worked, or moving from MTX to Cyclo thwarted a
rebound, or I wasn’t going to have one anyway.)
I want Xanelim
to work, even though I’ll probably try another biologic first (Enbrel,
if they ever make enough it) because I suspect the current rule of thumb,
that nothing works forever, hasn’t been overruled by the new drugs.
I hope I’m wrong! — But I’m not banking on it.
And, if it’s true that these new drugs, like their predecessors,
will eventually lose effectiveness for any specific patient, we will still
want alternatives. We need the
arsenal and I’m glad new technologies are providing fresh choices.
Stay in touch,
Howard. We’ll want to know
when you get on a Xanelim regimen and how it goes.