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Drugs Triggered P Flare?
Not sure if you are interested in non-associated drug interactions,
but thought I’d send this to you anyway.
have had plaque P on my elbows for 11 years, very mild, and had never had
it treated. I’d also never
had any type of “flare up.”
recently developed a cornea ulcer and was prescribed Ocuflox (an
ophthalmic antibiotic) and Alrex (an ophthalmic corticosteroid) to fight
the eye infection. During the
3 weeks of taking the steroid I had a moderate flare up of P (standard
plaque variety) on the back of my hands, calves and shins.
I had no recent life changes, no additional stress, and the steroid
/ antibiotic were the first prescription drugs I’ve ever taken in my
life. I’m a 33 year-old
male. I thought it was more
than just a coincidence.
it was worth informing somebody about (also sent this to NPF).
Neither my eye doctor nor my dermatologist knew of a link between
Alrex and P flare ups. When
my dermatologist prescribed Ultravate to treat the P, also a
corticosteroid, I wondered if there was a link between the medicine I took
for my cornea ulcer infection and the almost immediate flare up of P,
since they were both from the corticosteroid family.
this information is of use to the rest of the readers and perhaps somebody
else has had this unfortunate sequence of events as well and can confirm
or deny. -Paul D.
Response: No one with P is
lucky, Paul, but in one sense your ability to associate your flare with
the drugs is fortunate. You
have good reason to suspect one of your P triggers may be ophthalmic
corticosteroids, this particular one, or ophthalmic antibiotics, or that
particular one. Many of us
haven’t the foggiest clue what triggers our P!
Most of us have suspicions with nowhere near the cause-effect
evidence you’ve related.
not surprised your docs had not heard of any association between the drugs
you were prescribed and your P. Derms
have less of a handle on what triggers P than flakers do — probably
because they see so many dissimilar cases whereas a typical flaker studies
one case, his or her own.
topical corticosteroids are perhaps the most frequently prescribed
psoriasis therapy, they are known to have the reverse effect, to make P
worse. One might wonder why
your derm prescribed Ultravate if there was reason to suspect a
corticosteroid may have triggered your flare.
I don’t know, but I suspect your derm was leaning on the
distinction between a topical and an ophthalmic.
If you’re careful with the topical it may never penetrate beyond
your skin in significant quantity to trigger anything.
But might an ophthalmic behave differently?
Please let us know how you fare as time goes on. -Ed