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— A Fast Clearing Topical?
Hello Ed. My name is Natalie. I was wondering if you’ve heard anything about cyclopamine? If you look it up there are several interesting articles about it being able to clear P very rapidly with long remission times. There is even a U.S. patent on its use.
The only problem is I can’t seem to find any clinical trials being done so this product can be made available to the public. I did see two new topicals for P — the same old steroids with different brand names. I think that is shameful. Other than the biologics, for which many of us are not candidates, there really has not been anything new for P in years. Sorry just venting. -Natalie
Ed’s Response: No apologies accepted for venting, Natalie. FlakeHQ is a “vent outlet.”
I was NOT aware of cyclopamine, but did some web research, as you noted. Here is the abstract of an article about an experiment using cyclopamine on psoriasis lesions.
Here is a press release regarding the cyclopamine experiment.
The truly unique results obtained seem to me to be the rapid clearance of lesions using cyclopamine topically (lesions disappeared entirely in 3-4 days). How many of us have dreamed about a medicine that would clear us quickly — for a special event, a trip to the Beach, a blind date...!
Like you, Natalie, I didn’t find anything about clinical trials. I was surprised to find no references to cyclopamine at the NPF web site.
WebMd.com contained a couple of articles on cyclopamine. One reveals that the compound comes from the corn lily plant that grows in mountain meadows in the Western U.S. (Hell for breakfast! That’s where I grew up!)
By searching the U.S. Government Patent and Trademark Office web site, I found 9 patents involving cyclopamine; patents for a variety of “claims” including controlling unwanted hair growth, treating diabetes, and cholesterol control. I didn’t read all the documents, but those that I did skim did not mention psoriasis.
What to make of it all?
I really don’t know. I wish I could go home (Colorado), find some corn lilly weed in the mountains, run the plant through a blender until I got something smooth-on’able. Then glomb it on myself. If it worked, I wouldn’t give a damn about the patents (my feeling is weeds in Colorado belong to everybody).Anybody else have information about cyclopamine? -Ed