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to Try Amevive First ... Lifestyle Questions
Ed. Thank you for the information you are providing about psoriasis.
daughter developed psoriasis in 2000, at age 25. She is not into
researching, so I am trying to help her.
She is to begin Amevive treatments March 22.
She hasn't received her CD+4 counts yet. Her Dr. also required a TB
test, which was negative. Her only treatments prior to this, have been
ointments and steroid shots in the elbows. Have you had any persons relate
to you that when they began Amevive, they had not yet received any
systemic treatments? I am
hoping this will be a benefit.
Dr. wanted to start Soriatane [acitretin] last year but that was
postponed. My daughter is the
first patient her Dr. has put on Amevive.
would like very much to know if lifestyle affects psoriasis.
I know my daughter does not drink water. She is a soda junkie. She
also smokes. And I know she has very dry skin. Nor does she exercise. When
she developed psoriasis, she had changed jobs and her stress level was up.
No one else in our family has it. Perhaps comparisons made could help
others. It is my hope that she
can keep the arthritis at bay. Are
there any known factors that may cause the psoriasis to develop into
arthritis? Such as severity,
length of disease, treatments, etc.?
this is so long but anything that can help her and help others with
psoriasis would be great. Sorry to hear about your CD+4 count being low
and enjoyed reading your rebound diary. Thanks so Much. -Linda C.
Response: Hello Linda, thanks
for writing. Somewhere between
1 and 3 out of 10 people with P develop P Arthritis.
I think the range hasn't been narrowed because so many cases are
misdiagnosed. As far as I
know, there is no way of predicting if a particular individual with P will
also get PA. When there is a
family history the odds, naturally, change for the worse.
lifestyle effect psoriasis? Probably.
As you know, there are two faces to the disease: proclivity and
triggers. Proclivity, we
believe, is a genetic predisposition that we can't do anything about.
Triggers, on the other hand, can be difficult to ascertain and many
of them (perhaps MOST of them) have to do with external stimuli
(environment and lifestyle) or external stimuli that becomes internalized
(stress, diet, smoking, drinking....).
every excess a human can obtain has been considered a psoriasis trigger.
Surely everything you've mentioned that could be criticized about
your daughter's lifestyle has been thought to trigger P for some ... not
drinking enough water, too much soda (too much sugar), smoking....
Dry skin may or may not trigger psoriasis, but it certainly
exacerbates it! Lack of
exercise? Yes, that too has
been considered a trigger, especially as it relates to overall health and
stress reduction. Stress, of
course, is constantly blamed.
derm's decision to try Amevive before your daughter has been on any
systemic regimens doesn't surprise me at all.
The only reason so many people at FlakeHQ have tried other things
before the biologics is that we PREDATE the biologics.
I imagine most adults who are just now "getting P" will
be offered biologic therapies BEFORE things like methotrexate,
cyclosporine and acitretin. The
reason is because, in theory, the biologics should be much safer —
nothing about them is known to be toxic or to present other long-term
risks (although it's too early to express confidence in any long-term
don't let your daughter become too disappointed if Amevive doesn't work
for her. Anecdotally it
appears that Amevive is the least effective of the biologic quartet
currently available (Enbrel, Amevive, Raptiva, Remicade).
If she doesn't respond well to Amevive it does not mean she won't
respond well to one of the others.
Let us know how things progress. -Ed
Let us know how things progress. -Ed
If for any reason your daughter or her doctor think again about using
Soriatane, please make sure she reads all the literature online about that
drug's awful consequences relating to pregnancy. If my math is
right, she's still of child bearing age. If that's an issue, she may
want to try anything else before she tries Soriatane.