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About Enbrel Trial
You have a wonderful, informative site and I just want this opportunity to
say hello and to thank you for maintaining the site.
was diagnosed with PA over 15 years ago.
The P has gotten increasingly worse over the years while my A was
in remission after I started a serious exercise regimen in 1996 or so.
After I stopped jogging in 2003 on advice that impact exercise will
further damage my degenerating lumbar disk, my arthritic pain came back in
full force. In Nov 2003, my
left ankle, foot and leg became swollen and then became severely painful.
I ran to a cardiologist to make sure it's not my heart.
Then to a rheumatologist who wanted to put me on Enbrel.
Since I am not keen on injections we settled on 7.5 mg of weekly
MTX. While the swelling is
gone after 4 months, I am still in enough pain to affect the way I walk.
I am 54 and I walk like I'm 90.
My dermatologist is starting a clinical trial of Enbrel and I am a
perfect candidate. I'll be
doing 50 mg, 2 times a week. I
think that's double what you [Ed] started with.
advice or wisdom you can give would be much appreciated.
The trial starts 5/11! And
I'm still unsure what is the right thing to do!
Despite being without MTX for 3 weeks now, my pain has not
increased and has even lessened on some days.
It's all a mystery. My
P on the other hand is getting worse.
What I've read on your site has been that Enbrel was not so
effective on P for most. (I
looked at only the first 30 hits.) What's
the percentage of success stories from your readers?
you for listening. -Samantha T.
I hope you’ve gone ahead and started the Enbrel trial, Sam.
Though a lot of the early posts here about Enbrel were negative —
and we still get reports from Flakers who, like me, have found Enbrel
disappointing — the percentage of success stories is significant and
growing larger every day. Many
more satisfied users have left their impressions on
and it may be worth your while to
browse through those messages when you have some time.
has been considerable off-label use of Enbrel at 50 mgs twice weekly,
though the standard prescribed dosage is half that, as you pointed
out. It would appear the trial
in which you are participating (I hope) is intended to provide some
credible statistics on the efficacy of Enbrel — at least at the onset of
therapy — at this double-dose level.
In retrospect, I wish I had started it at 50 mgs twice weekly.
I used the 25 mgs twice weekly for my first three months on Enbrel,
then it was upped to 50 mgs. By
that time my body might have already said oh hell, ignore this stuff.
Starting out at 50 might have shocked my body into a better
response early on. (I use the
expression “shock” very figuratively.
One of the benefits of Enbrel, like the other biologics, is its
subtle effect on the immune system. The
way I understand it, even at a very strong dose there should be little or
no effect beyond its intended interference with specific T-cell
us know, Sam, if you started the trial and how it’s going if you have.