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Consequences of Soriatane for PRP Victim
I am 46 six years old and have had PRP since late 1998. Interesting
enough, I agree that it is been a most interesting as well as painful
progression over the past years.
Initially I was
misdiagnosed with a different disease and got a severe infection in my
liver that had to be cured first, thus was not able to start the treatment
for the PRP with Soriatane until three months later. By then the PRP had
encompassed most of my body.
I am being
treated by several dermatologists, which have to monitor my blood profile
carefully each month as you know due to the fact that this is a very
dangerous medication. My doses changes from 50 mg to 75 mg per month
according to the blood work up. In the year 2000, I was subsequently
diagnosed with Fuchs Corneal Dystrophy. Ironically by researching the web,
I found the connection between the Soriatane and the Fuchs Corneal
Now the date is
April 7, 2003 and I need two new corneas for my eyes. I was also told 5
days ago that I have to stop the Soriatane treatment due to hepatotoxicity
(liver dysfunction) from long term use from this medication.
The additional pain was incredible to say the least.
blood work profiles and don't be afraid to tell your Physician everything
that is going on with you, no matter how little or unimportant you may
think the change is. Keep in mind, there is not much known about this
disease. The PRP has now started to come back after getting off the
Keep a good
attitude and believe it will go into remission one day. It know I will. I
have met several people who have been cured over years of treatment with
use of Soriatane and a caring Physician. Sincerely, -Dan M.
Response: WebMD.com defines Pityriasis Rubra Pilaris (PRP) this way:
Rubra Pilaris is a mildly itchy chronic skin disorder that is possibly
caused by an inherited metabolic defect. Initially, the disorder is
characterized by elevated spots (papules) on the skin. These spots grow
and become connected, producing red plaques over large areas.
here to go to the page containing this quote.)
I checked some
of the adverse events recorded
at the www.soriatane.com
web site. Scanning for eye
disorders I found Xerophthalmia was frequently
reported, corneal epithelial and
corneal ulceration were less
frequently reported. At
WebMD.com I found this definition for Xerophthalmia:
dryness and thickening of the surface of the conjunctiva and cornea due to
a deficiency of vitamin A or to local disease.
listed many kinds of corneal dystrophy, but not “Fuchs,” specifically.
About corneal dystrophy disorders in general, that site says this:
Dystrophies are disorders affecting the outer clear layer of the eyeball
known as the cornea. They are caused by faulty metabolism in the tissues
in and around the eye. Clarity of vision is usually impaired by clouding
of the cornea.
I would add to
your most appropriate cautions to us all, Don, that the fine print
“adverse reactions” included in drug literature are only “remote
chances of bad reaction” until they happen to you.
should be a wake-up call to all those using Soriatane or thinking about
it. As you said, it is still a
good drug, but any physiological changes should be noted at once.