|May-June '03 | briefing | mail | don't say this | flakers' jargon | flaker creativity | articles | other places | archives | send mail | ed dewke | legal stuff | order | search | ©2001 Ed Dewke|
One Develop an Immunity to Biologics?
Gulliver (my derm in St. John's, Newfoundland) is conducting a
Remicade is a "biologic" drug — can my system become
eventually immune to biologic drugs? –Scott
Response: That’s a good
question, Scott, and I’ve not heard it directly addressed in talk or in
Remicade is in
the same biologic family as Enbrel — so-called TNF inhibitors — and
Enbrel has been used for a long time by arthritis patients.
I’ve not heard of immunities — or gradual desensitization —
occurring to patients under either drug.
Of course, one must look deeply to learn about this problem with
more conventional drugs like clobetasol propionate and betamethasone (the
active ingredients in a number of topical creams and ointments used for P)
— even though it’s common knowledge in our community that they do lose
effectiveness during continuous use over time.
on Remicade or Enbrel have asked their doctors about this and gotten an
educated response. If so,
please share with us. –Ed