Mar-Apr '08 | briefing | mail | interviews | articlespsorchat |  don't say this | flaker creativity | flakers' jargon | other places | archives | send mail | ed dewkesearch | acknowledgments | legal stuff | Flake: Confessions of a Psoriatic  | ©2008 Ed Dewke

Elidel for Psoriasis
from Stu M.

Hi Ed:  My GP recommended Elidel for psoriasis on the delicate skin on the face. I've spent a couple of years using this to suppress P lesions and, though the medication is designed for eczema, I can say it has made a substantial difference to the state of P in this area (nose/ears/hairline).

Unfortunately, for other, less delicate areas, it has made little or no difference (I have moderate to severe P across the usual areas of torso and limbs). I just thought I'd drop you a note and let you know the success I'd had with this product. In addition, I have noticed minimal rebound affect with Elidel vs traditional steroids.

I hope that some other readers may persuade their derms that they might be able to try Elidel with the same success I’ve had.

Cheers, -Stu M.


Ed’s Response:  Thanks for the report on Elidel, Stu.  Elidel (pimecrolimus) is one of two topical calcineurin inhibitors discussed in this article at, Topical calcineurin inhibitors for atopic dermatitis.  Like many other drugs used by flakers, this is a class of immune suppressors that diminishes the inflammation characteristic of skin lesions — however, these drugs do it without the adverse effects of corticosteroids.

It's interesting that the two calcineurin inhibitors are Elidel (pimecrolimus) and Protopic (tacrolimus).  The latter, Protopic, has been mentioned here before (see Protopic® - New Topical for Hard-to-Help Places).

These drugs do not contain steroids and are considered "safe" for areas where topical corticosteroid use is avoided (face, genitals).  I would imagine they are worth trying if one has "worn out" the effectiveness of topical corticosteroids.  Like many flakers, before I started using systemics I established a rotation of topicals that moved me across the scale of steroid strength from mild to major (usually, one 60 gram tube at a time).  At that time I'd not heard of either Elidel or Protopic (I don't think they were available at that time).  Had they been, I probably would have used them in my rotation, to have at least SOME period of time where I was applying something that was NOT a corticosteroid.  -Ed

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