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Astronomer’s Pregnancy & Enbrel Dilemma
Once again, I'm grounded by the psoriasis. I was doing pretty well
with just UV light until December when it started to come back. My
Now, for you
psoriatic pregnant folks (or anyone else for that matter), don't do
what I did. I said, well, it's only a few months. I can tough it out. It
took about a month for me to become completely covered — even the palms
of my hands and soles of my feet. I have quarter-sized blotches all over
my face even. So at my last
Enbrel is FDA
category B, but I decided to take advantage of my university setting
and tracked down a biochemist. We sat down and discussed Enbrel.
If any of you
ever consider using Enbrel in pregnancy, here's what we concluded
— your body treats Enbrel like an antibody. There is a blood barrier
between you and your baby so that your immune system can't attack the
baby. So the Enbrel should not be able to pass through to the baby. And
for those interested in nursing, the Enbrel molecule is too big to
transfer into breast milk and would be destroyed by the baby's digestive
system even if it did.
So don't tough
it out — the psoriasis can spread very fast because pregnancy messes
with your immune system! –Christy D.
Response: Thanks for the
update, Christy. I know you
stopped using Enbrel with some trepidation and your decision to start
using it again was obviously made after lots of thought.
I dug this out
of the Raptiva U.S. prescribing literature...
Developmental toxicity studies have been performed in rats and rabbits at doses ranging from 60- to 100-fold higher than the human dose and have revealed no evidence of harm to the fetus due to ENBREL. There are, however, no studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
The “only if
clearly needed” phrase is most curious, isn’t it?
It surely sounds like a semantic C.Y.A. to me.
I expect that
over the next few years we will learn much about biologics and pregnancy
because there will be many prospective mothers facing your dilemma.
Please keep us
P.S. – How’s the Euro50 telescope coming along?