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Him Enbrel Reduces Skin P Without Entirely Eliminating It
Thought I'd give you an update on my Enbrel usage.
I had written earlier about my poor
results on Soriatane and the excellence of Enbrel.
When I started
Enbrel I initially was taking two 25mg shots per week.
I achieved great results but I stopped just short of clearing
completely. My arthritis
symptoms disappeared completely — so much so I had a hard time
remembering what they felt like. After
several months my psoriasis crept back slightly on one leg.
Not anything like pre-Enbrel, however.
Pre-Enbrel coverage 20-30% ; during Enbrel 1-5%.
With my P
creeping back my derm ok'd a higher (100mg/wk) dosage (thanks Ed, I became
aware of this from one of your e-mails).
This brought me closer to clearing but not quite as close as
before. Is my immune system
adapting...hmm? After three
months of this I stabilized just shy of clearing.
At this point my Derm said that it is recommended practice to
reduce dosage back down to 50mg. Thinking
I had hit a plateau that wouldn't change much based on dosage I agreed and
we decided to reduce the dosage. Soon
afterwards my P began creeping back. Three
months later my Derm and I met and we agreed for me to go back to 100mg
per week. Again my P got
better and stabilized just short of clearing.
This is where I am to this day.
experience: Great clearing,
arthritis symptoms disappeared, one temporary weeklong thrombosis near an
injection site that may or may not be related to the treatment (I think
yes, the official response was no).
And compared to
having P, giving myself injections is not a big deal.
Response: I love good news,
Kurt. Being on the opposite
side of the equation from you right now, your side looks like greener
pastures! I’m trying
Raptiva, which may help my skin but isn’t likely to do anything for my
P-arthritis, so it’s flaring BIG time.
You, on the other hand, are sustaining some problems with the skin
while on Enbrel but have forgotten
what P-arthritis feels like. The
last time I was able to claim I had forgotten what P-arthritis feels like
was the last time I was on methotrexate.
And, frankly, I don’t know if I’ll ever be there again.
about “Is my immune system adapting?” is perhaps the most important
question being asked about all the biologics for P right now.
And for good reason.
All of us who
live with this disease have come to know it as a restless beast that
eventually overcomes everything we do to try to contain it.
Now, along comes this new type of drug — made from natural
proteins, too delicate to survive administration in pill form, targeted to
very narrow immune system actions — and at least some of the
manufacturers are saying, Take it
forever! Enjoy clearance
forever! Who can blame us
for being somewhat cynical? Yet
last month Raptiva announced the end of a 3 year Raptiva user group study
(small number of subjects) that suggests many sustained their clearance
and experienced no adverse side effects.
Can it be true?
At this time, about all we can say is Stay Tuned. And Kurt, you stay in touch, too. -Ed