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Rebound for Drug Study
I have severe P
(over 50%) and am considering participating in a clinical study using
Avandia that is going on here in Southern Cal. While Dr. Mirkin’s claim
sounds promising, I have one huge problem. What if I am only receiving a
placebo instead of the actual drug? I'm
told I won't know. Does that mean I could have to go 13 months with no
improvement? Methotrexate works well for me, but makes me very ill.
After 20 years
of nothing working, I would give anything for a 'near' cure. Should I just
go for Enbrel and forget the study? Any response would be appreciated.
Thank you. -Steve T.
Response: As I understand it,
Steve, to keep the study valid they can't know and you can't know if
you're getting a placebo or the actual drug.
If you've been on MTX, and they're telling you to stop taking it to
participate in the study, you may be subject to a pretty nasty P rebound.
You should discuss this completely with the research physician and your
Enbrel with your derm. Do you
also have psoriatic arthritis? I've
received an email just the other day from a fellow who's been on Enbrel
for a number of years for his rheumatoid arthritis and also has P.
He writes the drug has never had an impact on his skin lesions, for
which he follows other regimens, including MTX!
So ... there seems to be a lot of unknowns about that one, too.
available now. Ask your derm
about that one, too.
What you're facing is the exact reason why I, personally, have not
attempted to participate in any double-blind drug studies of P
medications. It can take so
bloody long to overcome a bad rebound.....
But that's me. Let
me know what you decide. -Ed
Follow-up: Hello Ed.
I decided to do the study. I had already stopped MTX last year and
have been dealing with the rebound since then. I tried Soriatane for a few
weeks, but the dryness was too much to handle. I've been taking the
Avandia for about 2 weeks now. I could be getting the placebo, but I have
noticed some side effects and am hopeful I'm getting the real thing. If I
am getting the placebo, the study does put me on the actual drug after 26
After 20 years
of this damnable disease, 6 months doesn't seem like very long. So how is
the Enbrel going?
Best of luck in
your own P battle. –Steve T.
Response: Avandia (rosiglitazone
maleate) is a drug approved for the treatment of type 2 diabetes. Dr.
Gabe Mirkin, an M.D. from Maryland, claimed several years ago that the
drug also cleared three of his patients of their psoriasis. (See Dr.
Mirkin’s New “Cure”.)
manufactured by GlaxoSmithKline and, at their web site, I was able to find
one article about a current examination of the drug for alternative
therapies — but it wasn’t about psoriasis.
My inability to find information about the study Steve T’s
participating in isn’t, it itself, meaningful.
Steve: If there is specific information about the particular study in which you are participating, please let me know. Best of luck. -Ed