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Trial Subject Has Unusual Reaction
I am in a clinical trial for Raptiva — one of the new monoclonal
antibodies. I had a lot of
plaque psoriasis and have for about 27 years.
I have had about 4 of the injections that we knew for a fact was
Raptiva (the first twelve weeks could possibly have been a placebo).
About 2 weeks ago I began noticing that the plaques were sticky as
they came off and now they have pus under them.
The Dr. thinks it could possibly be pustular psoriasis.
Have you had anyone else with this problem?
I am about at the end of my rope!
I understand your frustration, Jan.
That is an interesting and no-doubt uncomfortable reaction you are
having. First a refresher.
(efalizumab), being tested by Genentech and Xoma, is another biologic drug
(in this case, a protein) that, like Enbrel, is administered through
subcutaneous injection. It
targets a particular type of cell in our immune system that is understood
to be involved in the generation of P plaques.
If effective, Raptiva “turns off” or “inhibits” the
activity of this cell that would result in P lesions.
For more information go to:
heard the appearance of pustular P described quite the way you have, here,
but that isn’t meaningful. This
is the page at the National Psoriasis Foundation that describes the
various forms of pustular P, and has a photo of one variety...
carefully, Jan, and see if it agrees with what you are experiencing.
Having said all
that, I have had plaque lesions that tended to “weep” when I scraped
away flakes. This isn’t
usual, and I’ve not taken much notice of it.
Bleeding is usual, especially when I’m not removing flakes
properly and carefully (e.g., when I’m just manically scratching a
lesion), but these rare “weepers” attract my attention because my
clothes will get a wet spot over the lesion, but upon investigation I see
it’s not blood. But is it
pus? It hasn’t seemed so to
Beyond determining just what it is you are experiencing, there is the study-related curiosity about why it’s occurring. Please keep us informed, Jan. Meanwhile, we’d appreciate hearing from any other readers who may have had similar experiences on or off the Raptiva trial. Thanks, Jan. -Ed