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Relapse after Anti-cd11a (Xanelim) Trial
Hi, I happened
to find you via Google, in the process of searching to see if there were
any new developments with anti-cd11a, for which I was a volunteer subject
for a couple of stages of the phase 3 testing that ended here last
February (2001). I was one of
the ones who went through severe relapse about six weeks after ending the
treatments, and unfortunately my self-proclaimed-genius derm wasn't the
type who believed in hospitalization.
whether anyone else who used that drug has experienced long-term
after-effects that seem to be tied to it, as I have?
In particular, areas around my ankles can become quite tender and
sensitive to even the slightest friction, and if I don't cushion them they
may open into small ulcerated patches that take forever to close over
properly again. My derm
couldn't be bothered with them, other than to set me up for home care for
bandaging. Anyone else gone
through this, and better yet, had any feedback as to how long before this
problem gives up and returns to "normal" P?
I've got a new
derm now, out of town, and he seems quite reasonable.
He recognizes that I've been dealing with this for something like
40 years now (I'm mid-50's), and that I accept that 99 percent of the time
it's worse to look at than to have. He's
quite willing to be on "standby" in case of a flare-up, and he
does have privileges at a small but excellent local inpatient/outpatient
And I like to
think positive (I'm also a brain-injury survivor, and that teaches you a
LOT about thinking positive). My
P is very stubborn, which is one of the reasons I was a top choice for the
anti-cd11a testing. But it's
also quite likely a good indication that I've got a very strong
immune/defense system. Most
bugs going around tend to pass me right by.
the "feel" of your site, and plan to be back often to see what's
happening. Best to all, -Mike
James asked (in
the Feb. mail) — Is an Electric
Razor Better for Face P? Obviously
I can only pass along two cents (got change?) based on my own experiences.
I switched to
an electric razor years ago mainly because I've got what has to be the
worst possible combination: a tough beard plus angular face plus the P.
I hadn't been aware of my old Gillette aggravating the P, but it
sure left a lot of trickling nicks behind.
And since, in my case at least, P tends to jump on “real”
injuries just as devoutly as on its own concept of injuries, I guess it
probably didn't help any.
I never was
crazy about electrics, especially back before my face “joined the
party,” because I've never seen one that shaved anywhere near as neat as
a blade. But a good rotary
with floating heads makes a not-too-bad second choice, especially on an
angular face like mine. –Mike
Response: Welcome, Mike.
Seems we’re collecting more war stories than success stories
about the anti-cd11a trials. (Anti-cd11a,
an experimental drug, is a new monoclonal antibody designed to prevent activation of T-cells, which
are considered a major factor in psoriasis.)
A search here on “anti-cd11a” reveals a number of emails,
including reports of joint pain, lesion flare-ups and migraine headache
upon ending the trial. Of
course, it could be that only folks with bad experiences are writing about
them here. We’ll have to
wait and see what becomes of the drug.
We should hear something soon. Go
here for a recent press release
about the drug — commercial name Xanelim — from the manufacturers,
Genentech and XOMA.
interesting that the coverage of Xanelim’s development and trials focus
on effects during treatment
(which is done by injection) and none of the things I have read have
talked about what happens when treatment is stopped; i.e., relapse or
side-effects. But it’s the
after-effects we’re hearing reports about here.
It will be interesting to see how Xanelim therapy is described
when/if it hits the streets.
Thanks for your
comments on electric vs. manual shaving.
It occurred to me, while reading your email, that there is another
reason we become more tolerant of electrics as we grow older.
At least, this is true in my case (though I’m still not using an
electric — too cheap to buy one). When
we get older the skin on our faces sags and wrinkles.
It’s no longer appropriate to worry about it being as smooth as a
baby’s behind because few people are going to want to stroke it anyway.
Am I right? -Ed