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Transdermal Gel Compounded with Topical Steroid Enhances Effectiveness
from Beth in Canada

Well, how do I start this? I have been visiting your site for the last three years. I have had P for four and a half years now, although I don't have it as bad as some. I recently moved to a small town in southern British Columbia (Canada), were I happened upon a miracle.

The thriving metropolis of Fruitvale has a Peoples Drug Mart, where a guy named Lou works. He subscribes to Pharmacy newsletters and whatever else there might be that Pharmacists subscribe to. Back in 1991, a newsletter came out about this new base compound, Pluronic Lecithin Organogel. What I know about this miracle compound is that it has cleared up my P almost completely. I have only been using it for one week and five days! Lou tried to explain how it works to me so I'll try to explain it to you. He takes your regular everyday Betamethasone and mixes it with the Lecithin at 3000 rpm, the Pluronic is the suspension agent (if that's what you would call it), that's the stuff that holds the Lecithin and Organogel together. Now that I have probably completely lost you I'll tell you why this stuff is so great.

The compound itself does not let the betamethasone into your blood, it keeps the cortisone on the top layers of your skin which in turn lets the cortisone work longer on the P. The tests that were done were done on rabbits, their hair was shaved off and the PLO gel was applied to the skin. After waiting however long, blood tests were done to check the cortisone levels, they came back perfectly normal! The reason we can only use cortisones for 2-weeks-on, 2-weeks-off intervals is because it ends up in our blood, which I guess isn't good. I was also told that you can't get this stuff at chain pharmacies, you have to go to a Pharmacy that mixes their own compounds. I hope you find this useful. -Beth in Canada


Ed’s Response: Pluronic Lecithin Organogel, a.k.a. PLO Gel, is a "penetrating enhancing transdermal gel." The Park Pharmacy in Irvine, CA had this to say at their web site, to which I was referred upon a web search for Pluronic Lecithin Organogel: 

"Tansdermal research has given us the ability to compound Percutaneous (Transdermal) Gels which allows medication to be absorbed through the skin for almost immediate results. These gels can be formulated to contain combinations of ingredients that provide quick relief without unwanted side effects such as: sedation, impaired cognitive function, stomach upset and ulceration, etc."

This is the first I’ve heard of it and I’m very glad you shared the information with us, Beth. The first thing I’m going to do is take a copy of this exchange with me on my next derm visit. Then I’m also going to share it with my pharmacist (he compounds ingredients, too).

I’d be interested in hearing if anybody else has had this PLO Gel compounded with their usual topical medications. (How well does it work through scale?) -Ed

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