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P and Primary Immune Deficiency Diseases:  An Association?
from Terri

Ed, I have no idea if you will get this.  I just ran into your diary from 2004 while looking up info about chapped lips.

I am sorry if this sounds blatantly stupid, but have you been checked for primary immune deficiency disease?

I have it and my children have it.  Prior to treatment, I had terrible joint pain as well as psoriasis-like problems on every part of my body — that looked like yours.  I found out that I have Common Immunodeficiency disease.  After over 40 years of fighting all these problems, I started IVIG [intravenous immunoglobulin] last spring and, to my surprise, my psoriasis and joint pain were gone in a week and never returned.

I have low B cells, low NK (killer T) cells, specific antibody disorder, complement CD3 and CD56 disorders.

Just something you might want to look at if you have not already.  If you have not, I am not sure what part of the country you live in, but contact the national immune deficiency foundation and they will put you in touch with a well qualified immunologist for evaluation.

Good luck!  -Terri


Ed’s Response:  Thanks Terri.  I did get this and will follow-up on your suggestion.  Can you tell me, is Common Variable Immunodeficiency another name for what you are writing about? -Ed


Terri’s Response:  Yes, Ed.  We have been diagnosed with CVID, one of 120 known types of immune disorders that can be characterized in adults with joint pain, skin and  eye problems.

Let me know how it goes.  The website for the Immune Deficiency Foundation is primaryimmune.org.

I am a patient advocate for them.

Good Luck! -Terri


Ed’s Response:  Spending some time at the Immune Deficiency Foundation website is fascinating.  I’m thinking — but am by no means confident in my thinking so far — that psoriasis is not on the list of “primary immune system diseases” because it typically isn’t characterized by any sort of immune system “shut down.” 

The immune system “mistakes” that characterize psoriasis are typically not “shut downs,” but normal immune system processes that are happening where and when they ought not be. 

I think what brought Terri’s eye to my case, in the Rebound Diary from 2004, was my shockingly low CD+4 cell count.  It was too low for me to take Amevive and measuring at levels HIV patients experience when their conditions decay into full-blown AIDS.  That DOES sound like an immune system “shut down.”

I’d be very interested in hearing from anyone else who has info or insight about the relationship between psoriasis and primary immune deficiency diseases.  -Ed

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