|Jan-Feb '05 | briefing | mail | don't say this | flakers' jargon | flaker creativity | articles | other places | archives | send mail | ed dewke | legal stuff | order | search | PsorChat | PsorChat Review | ©2004 Ed Dewke|
I live in
I would also
really appreciate if it people could mail me as I am housebound due to
very severe PA for which one consultant wants me to take methotrexate.
I would be grateful for any advice you guys could give me and would
love to hear from people in
Response: You are right to be
concerned about cyclosporine with your liver situation.
As I write this I’m dosing down to conclude another 10 months on
cyclo and the drug has elevated my blood pressure, caused significant
edema in my legs, greatly accelerated body hair growth (which can be an
unimaginable irritation!) and required frequent blood work-ups to check
for liver and kidney anomalies. Having
said all that, cyclosporine is the one and only drug I’ve taken that can
— though it didn’t this time — completely eliminate any visible
psoriasis on me.
pitched as a psoriatic arthritis (PA) drug — like methotrexate — but
for some of us — including me — it does reduce the pain of PA while it
dramatically improves skin P. I
don’t typically notice the reduction in pain while I’m on the drug,
but as soon as I dose-down (to wean myself off the drug) and when I’m in
the inevitable re-bound the increase
in PA pain certainly suggests that it had been doing something
to keep it down.
If your more
severe condition is PA, Jacqui, I’m surprised cyclosporine would be
considered in lieu of methotrexate (MTX), because MTX is the most
prescribed systemic for the treatment of severe PA.
However, MTX can be even more
damaging to the liver than cyclo (which seems to hit kidneys harder).
Since you already have drug-related liver problems, it does not
surprise me that at least some doctors discourage your use of MTX.
Jacqui, I hate
to say things that can’t be acted upon, but perhaps you could inquire in
meantime, if MTX or cyclosporine are in your future, you must know that
tens of thousands of us have used these drugs safely by carefully
following dosing instructions and maintaining our regularly scheduled lab
tests and follow-up examinations. Your
doctors know your risks. The
benefits can be powerful. Before
I tried either of these drugs I was afraid of them both (my liver wasn’t
in very good shape, either). But
when I came close to becoming housebound because of PA I finally said
“okay” to methotrexate and have since used the drug on-and-off
continually. It almost
completely negates my psoriatic arthritis pain.
I don’t even have to take painkillers while I’m taking
Stay in touch, Jacqui. We want to know how you are doing. -Ed